Methadone Maintenance 4 Decades Later

Pseudorandom Functions: Three Decades Later

In 1984, Goldreich, Goldwasser and Micali formalized the concept of pseudorandom functions and proposed a construction based on any length-doubling pseudorandom generator. Since then, pseudorandom functions have turned out to be an extremely influential abstraction, with applications ranging from message authentication to barriers in proving computational complexity lower bounds. In this tutori...

Methadone maintenance treatment.

Methadone maintenance treatment and drugs.

The mental and physical capabilities of drivers in traffic are often seriously challenged these days. Not only do they need to concentrate on driving, predict connections between various phenomena, take appropriate judgements in current situations and foresee the sequence of measures to be taken, but they are also expected to be emotionally stable, etc. The problem with drugs in traffic is ofte...

Availability of outpatient methadone maintenance

Background Multiple forms of effective treatment for opioid use disorders (OUDs) exist, but they have remained in short supply and have been underutilized where available. Simultaneously, OUDs persist as a large and growing public health problem across the United States, leading to epidemic levels of overdose death as well as many other damaging societal consequences. Our goal was to assess the...

Acute respiratory distress syndrome--two decades later.

Twenty years have now elapsed since Ashbaugh and Petty first described the syndrome of acute respiratory failure associated with a wide spectrum of clinical conditions. During the past two decades, significant advances have emerged in our understanding of the clinical conditions associated with the syndrome and the pathophysiological changes affecting the alveolar-capillary membrane responsible...